Ex vivo cardiac DTI: on the effects of diffusion time and b-value
نویسندگان
چکیده
Background For in-vivo an ex-vivo studies of myocardial structure, generally a spin echo (SE) or stimulated echo (STE) based sequence is used. Diffusion weighting is reported with a large range of diffusion times (50 and 1000 ms). Furthermore, in-vivo studies generally use low b-values (300 s/mm) whereas ex-vivo experiments allow for much higher b-values. For interpretation of in-vivo cardiac DTI a understanding of the effects of sequence parameters on the derived diffusion parameters is needed. In this study, we therefore studied the impact of diffusion time and b-value on these parameters.
منابع مشابه
Resolving Fine Cardiac Structures in Rats with High-Resolution Diffusion Tensor Imaging
Cardiac architecture is fundamental to cardiac function and can be assessed non-invasively with diffusion tensor imaging (DTI). Here, we aimed to overcome technical challenges in ex vivo DTI in order to extract fine anatomical details and to provide novel insights in the 3D structure of the heart. An integrated set of methods was implemented in ex vivo rat hearts, including dynamic receiver gai...
متن کاملValue of Formalin Fixation for the Prolonged Preservation of Rodent Myocardial Microanatomical Organization: Evidence by MR Diffusion Tensor Imaging.
Previous ex vivo diffusion tensor imaging (DTI) studies on formalin-fixed myocardial tissue assumed that, after some initial changes in the first 48 hr since the start of fixation, DTI parameters remain stable over time. Prolonged preservation of cardiac tissue in formalin prior to imaging has been seen many times in the DTI literature as it is considered orderly. Our objective is to define the...
متن کاملThe impact of signal-to-noise ratio, diffusion-weighted directions and image resolution in cardiac diffusion tensor imaging – insights from the ex-vivo rat heart
BACKGROUND Cardiac diffusion tensor imaging (DTI) is limited by scan time and signal-to-noise (SNR) restrictions. This invariably leads to a trade-off between the number of averages, diffusion-weighted directions (ND), and image resolution. Systematic evaluation of these parameters is therefore important for adoption of cardiac DTI in clinical routine where time is a key constraint. METHODS H...
متن کاملComparison of In Vivo and Ex Vivo Diffusion Tensor Imaging in Rhesus Macaques at Short and Long Diffusion Times
Diffusion tensor imaging (DTI) is widely used to non-invasively study neural tissue micro-structure. While DTI tractography of large nerve fibers is well accepted, visualization of smaller fibers and resolution of branching fibers is challenging. Sensitivity of DTI to diffusion anisotropy can be further enhanced using long diffusion time that can provide a more accurate representation of the ti...
متن کاملIn vivo human cardiac fibre architecture estimation using shape-based diffusion tensor processing
In vivo imaging of cardiac 3D fibre architecture is still a practical and methodological challenge. However it potentially provides important clinical insights, for example leading to a better understanding of the pathophysiology and the follow up of ventricular remodelling after therapy. Recently, the acquisition of 2D multi-slice Diffusion Tensor Images (DTI) of the in vivo human heart has be...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 16 شماره
صفحات -
تاریخ انتشار 2014